The global law firm has taken 27,500 sq ft across three floors of the 19-storey building.
No. 1 Spinningfields is currently being built and is due to complete in 2017.
ID:SR will work closely with Squire Patton Boggs on the unique office design and fit out of its headline space.
The final design will put employee well-being and productivity first and showcase and support the firm’s core brand values.
Marie Leyland, head of ID:SR North at Sheppard Robson said: “Squire Patton Boggs require world-class facilities to match the pace of the global market and this is why they have committed to space at No. 1 Spinningfields.
“As part of our activity-driven approach we are developing the design through extensive consultation with Squire Patton Boggs’ employees in order to provide a space, which can evolve with the needs of the business and be flexible to accommodate all aspects of the practice.
“We are privileged to be working with them to create an extraordinary workspace in one of Manchester’s most sought-after developments.”
Allied London is delivering No. 1 Spinningfields, which is expected to be the finest and highest specified business environment in Manchester.
It will boast a rooftop bar, restaurant and terrace, a premium business lounge, innovative amenity and flexible fit-out options.
Rob Elvin, managing partner of Squire Patton Boggs in Manchester, said: “We have a long and proud history in Manchester and, working with Sheppard Robson, we are looking to create a prestigious office to match our local and international aspirations and give us a platform for the firm’s future in the city.”